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Javier Lopez quotes

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    I Like this quote I dislike this quote“While some scientists have suspected that large introns might
not be removed in one piece through direct splicing, no one had
identified how this could happen. Now we have identified a way,”

 Javier Lopez quote

 Add to Chapter...
    I Like this quote I dislike this quote“We found that many large introns are removed by multiple
recursive splicing steps, ... These steps involve the
sequential excision of smaller subfragments. Our work also indicates
that most recursive splicing events leave no clues in the final mRNA.
This is why they have not been detected before now.”

 Javier Lopez quote

 Add to Chapter...
    I Like this quote I dislike this quote“Our experimental results agreed with the computational
findings, indicating that these ratchetting points mediate the removal
of intron subfragments in one direction as the gene is transcribed
initially from DNA into RNA,”

 Javier Lopez quote

 Add to Chapter...
    I Like this quote I dislike this quote“The striking evolutionary conservation of ratchetting points
suggests that recursive splicing provides specific advantages for large
introns, ... One possibility is that recursive splicing
prevents the generation of long RNA transcripts that could form
structures that interfere with correct processing into mRNA. Another is
that recursive splicing might help stimulate transcription through long
introns by promoting interactions between the splicing and
transcription machineries. We also know already that recursive splicing
is used to control the removal of certain exons from mRNAs, generating
structural and functional variation among the gene products.”

 Javier Lopez quote

 Add to Chapter...
    I Like this quote I dislike this quote“While some scientists have suspected that large introns might not be removed in one piece through direct splicing, no one had identified how this could happen. Now we have identified a way,”

 Javier Lopez quote

 Add to Chapter...
    I Like this quote I dislike this quote“We found that many large introns are removed by multiple recursive splicing steps, ... These steps involve the sequential excision of smaller subfragments. Our work also indicates that most recursive splicing events leave no clues in the final mRNA. This is why they have not been detected before now.”

 Javier Lopez quote

 Add to Chapter...
    I Like this quote I dislike this quote“Our experimental results agreed with the computational findings, indicating that these ratchetting points mediate the removal of intron subfragments in one direction as the gene is transcribed initially from DNA into RNA,”

 Javier Lopez quote

 Add to Chapter...
    I Like this quote I dislike this quote“The striking evolutionary conservation of ratchetting points suggests that recursive splicing provides specific advantages for large introns, ... One possibility is that recursive splicing prevents the generation of long RNA transcripts that could form structures that interfere with correct processing into mRNA. Another is that recursive splicing might help stimulate transcription through long introns by promoting interactions between the splicing and transcription machineries. We also know already that recursive splicing is used to control the removal of certain exons from mRNAs, generating structural and functional variation among the gene products.”

 Javier Lopez quote

 Add to Chapter...
    I Like this quote I dislike this quote“That's just our hogs stepping up the occasion.”

 Javier Lopez quote

 Add to Chapter...
    I Like this quote I dislike this quote“We changed things up and were running some totally different things than they've seen. They saw some different things and it looked like they were a little confused, and our defensive line just put a lot of pressure on them.”

 Javier Lopez quote

 Add to Chapter...
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